Chondroitin Sulfate/Cyanocobalamin–Chitosan Polyelectrolyte Complexes for Improved Oral Delivery of Colistin

Chondroitin Sulfate/Cyanocobalamin–Chitosan Polyelectrolyte Complexes for Improved Oral Delivery of Colistin

Introduction. The rise of multidrug resistance in Gram-negative ESKAPE pathogens is a critical challenge for modern healthcare. Colistin (CT), a peptide antibiotic, remains a last-resort treatment for infections caused by these superbugs due to its potent activity against Gram-negative bacteria and...

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Main Authors: Natallia V. Dubashynskaya, Andrey Y. Borovskoy, Anton N. Bokatyi, Tatiana S. Sall, Tatiana S. Egorova, Elena V. Demyanova, Ekaterina A. Murashko, Yury A. Skorik
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Polysaccharides
Subjects:
colistin
chondroitin sulfate
cyanocobalamin–chitosan
polyelectrolyte complexes
intestinal permeability
Online Access:https://www.mdpi.com/2673-4176/6/1/21
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