KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation

KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation

ABSTRACT RNA alternative splicing is a fundamental cellular process implicated in cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of multiple human malignancies, including Kaposi’s sarcoma (KS), remains a significant concern, particularly in AIDS patients. A...

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Bibliographic Details
Main Authors: Shenyu Sun, Ling Ding, Karla Paniagua, Xian Wang, Yufei Huang, Mario A. Flores, Shou-Jiang Gao
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Kaposi’s sarcoma (KS)
Kaposi’s sarcoma-associated herpesvirus, KSHV
RNA splicing
FAM50A
SHP2
STAT3 activation
Online Access:https://journals.asm.org/doi/10.1128/mbio.01293-25
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https://journals.asm.org/doi/10.1128/mbio.01293-25

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