Efficacy of Polyphenylene Carboxymethylene (PPCM) Gel at Protecting Type I Interferon Receptors Knockout Mice from Intravaginal Ebola Virus Challenge

Efficacy of Polyphenylene Carboxymethylene (PPCM) Gel at Protecting Type I Interferon Receptors Knockout Mice from Intravaginal Ebola Virus Challenge

Ebola virus (EBOV) is one of three filovirus members of the <i>Orthoebolavirus</i> genus that can cause severe Ebola disease (EBOD) in humans. Transmission predominantly occurs from spillover events from wildlife but has also happened between humans with infected bodily fluids. Specifica...

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Bibliographic Details
Main Authors: Olivier Escaffre, Terry L. Juelich, Jennifer K. Smith, Lihong Zhang, Madison Pearson, Nigel Bourne, Alexander N. Freiberg
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Viruses
Subjects:
Ebola virus
microbicide
PPCM
sexual transmission
intravaginal infection
IFNAR<sup>−/−</sup> mice
Online Access:https://www.mdpi.com/1999-4915/16/11/1693
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