Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination

Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination

Failure of myelin regeneration by oligodendrocytes contributes to progressive decline in many neurological diseases. Here, using in vitro and in vivo rodent models, functional blockade, and mouse brain demyelination, we demonstrate that Sonic hedgehog (Shh) expression in a subset of oligodendrocyte...

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Bibliographic Details
Main Authors: Mariagiovanna Russo, Amina Zahaf, Abdelmoumen Kassoussi, Ariane Sharif, Hélène Faure, Elisabeth Traiffort, Martial Ruat
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
demyelinating disease
platelet-derived growth factor receptor alpha
hedgehog signaling
post-natal brain
AAV vectors
Online Access:https://www.mdpi.com/2073-4409/13/21/1808
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