Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells

Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells

Introduction: Cirrhosis is a disease with poor prognosis that requires the development of a novel therapeutic approach alternative to liver transplantation. In this study, we focused on the placenta and aimed to clarify the effects of human placental extract (HPE) on cirrhosis. Methods: A mouse mode...

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Main Authors: Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Regenerative Therapy
Subjects:
Human placental extract
Spatial transcriptomics
Liver cirrhosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320425000173
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