Asymmetric total synthesis of benzenoid cephalotane-type diterpenoids through a cascade C(sp2) & C(sp3)–H activation

Abstract Cephalotane diterpenoids, featuring unique and complicated carbon skeletons and remarkable antitumor activities from the Cephalotaxus genus, have been gaining increasing attention. Herein, we report the asymmetric and divergent total synthesis of benzenoid cephalotane-type diterpenoids cont...

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Bibliographic Details
Main Authors: Xiangxin Li, Zhaoxu Lu, Shaocong Liu, Mengyao Sun, Shengfu Duan, Zhixiang Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59816-w
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