A novel, synthesized, amphiphilic ethylene glycol squalene derivative suppresses BBN-induced bladder carcinogenesis

A novel, synthesized, amphiphilic ethylene glycol squalene derivative suppresses BBN-induced bladder carcinogenesis

Abstract Squalene, a natural triterpene with antioxidant, anti-inflammatory, and immunostimulatory properties, holds promise for cancer therapy. Here, we examined a previously developed, diethylene glycol derivative of squalene (SQ-diEG) and investigated its in vivo anti-carcinogenic effects in blad...

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Main Authors: Keisuke Sano, Masanobu Shiga, Farhana Ferdousi, Hiromichi Sakurai, Kazuki Hamada, Kozaburo Tanuma, Satoshi Nitta, Yoshiyuki Nagumo, Shuya Kandori, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Jun Miyazaki, Tran Ngoc Linh, Takashi Arimura, Hiroko Isoda, Hiroyuki Nishiyama
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Squalene
Ethylene glycol derivative
Bladder cancer
Apoptosis
SQLE
Cholesterol metabolism
Online Access:https://doi.org/10.1038/s41598-025-16225-9
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https://doi.org/10.1038/s41598-025-16225-9

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