Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart

Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart

Abstract Lung cancer and cardiovascular disease pose persistent threats to human health, despite advancements in targeted therapy, percutaneous coronary intervention, and drug treatments. Challenges such as side effects, drug resistance, hospitalization rates, and mortality remain high. These diseas...

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Bibliographic Details
Main Authors: Tingting Bai, Quan Wan, Changcheng Yue, Jingjing Wang, Shichao Deng, Xueying Shen, Hongqing Wang, Liyan Huang, Dong Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Cardiovascular disease
Spatial metabolomics
4D-DIA quantitative proteomics
Space mass spectrometry
Lung cancer
Online Access:https://doi.org/10.1038/s41598-025-97821-7
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https://doi.org/10.1038/s41598-025-97821-7

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