Biomaterial Applications in Cell-Based Therapy in Experimental Stroke
Stroke is an important health issue corresponding to the second cause of mortality and first cause of severe disability with no effective treatments after the first hours of onset. Regenerative approaches such as cell therapy provide an increase in endogenous brain structural plasticity but they are...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6810562 |
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| author | Ligia S. B. Boisserand Tomonobu Kodama Jérémie Papassin Rachel Auzely Anaïck Moisan Claire Rome Olivier Detante |
| author_facet | Ligia S. B. Boisserand Tomonobu Kodama Jérémie Papassin Rachel Auzely Anaïck Moisan Claire Rome Olivier Detante |
| author_sort | Ligia S. B. Boisserand |
| collection | DOAJ |
| description | Stroke is an important health issue corresponding to the second cause of mortality and first cause of severe disability with no effective treatments after the first hours of onset. Regenerative approaches such as cell therapy provide an increase in endogenous brain structural plasticity but they are not enough to promote a complete recovery. Tissue engineering has recently aroused a major interesting development of biomaterials for use into the central nervous system. Many biomaterials have been engineered based on natural compounds, synthetic compounds, or a mix of both with the aim of providing polymers with specific properties. The mechanical properties of biomaterials can be exquisitely regulated forming polymers with different stiffness, modifiable physical state that polymerizes in situ, or small particles encapsulating cells or growth factors. The choice of biomaterial compounds should be adapted for the different applications, structure target, and delay of administration. Biocompatibilities with embedded cells and with the host tissue and biodegradation rate must be considerate. In this paper, we review the different applications of biomaterials combined with cell therapy in ischemic stroke and we explore specific features such as choice of biomaterial compounds and physical and mechanical properties concerning the recent studies in experimental stroke. |
| format | Article |
| id | doaj-art-adc277f5bead43a39b8ceaa0a870ebdb |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-adc277f5bead43a39b8ceaa0a870ebdb2025-02-03T05:59:10ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/68105626810562Biomaterial Applications in Cell-Based Therapy in Experimental StrokeLigia S. B. Boisserand0Tomonobu Kodama1Jérémie Papassin2Rachel Auzely3Anaïck Moisan4Claire Rome5Olivier Detante6Inserm, U1216, BP 170, 38042 Grenoble Cedex 9, FranceInstitute for Frontier Medical Sciences, Department of Reparative Materials, Kyoto University, Kyoto 606-8507, JapanInserm, U1216, BP 170, 38042 Grenoble Cedex 9, FranceCERMAV, CNRS, CERMAV, Université Grenoble Alpes, 38000 Grenoble, FranceCell Therapy and Engineering Unit, EFS Rhône Alpes, 464 route de Lancey, 38330 Saint-Ismier, FranceInserm, U1216, BP 170, 38042 Grenoble Cedex 9, FranceInserm, U1216, BP 170, 38042 Grenoble Cedex 9, FranceStroke is an important health issue corresponding to the second cause of mortality and first cause of severe disability with no effective treatments after the first hours of onset. Regenerative approaches such as cell therapy provide an increase in endogenous brain structural plasticity but they are not enough to promote a complete recovery. Tissue engineering has recently aroused a major interesting development of biomaterials for use into the central nervous system. Many biomaterials have been engineered based on natural compounds, synthetic compounds, or a mix of both with the aim of providing polymers with specific properties. The mechanical properties of biomaterials can be exquisitely regulated forming polymers with different stiffness, modifiable physical state that polymerizes in situ, or small particles encapsulating cells or growth factors. The choice of biomaterial compounds should be adapted for the different applications, structure target, and delay of administration. Biocompatibilities with embedded cells and with the host tissue and biodegradation rate must be considerate. In this paper, we review the different applications of biomaterials combined with cell therapy in ischemic stroke and we explore specific features such as choice of biomaterial compounds and physical and mechanical properties concerning the recent studies in experimental stroke.http://dx.doi.org/10.1155/2016/6810562 |
| spellingShingle | Ligia S. B. Boisserand Tomonobu Kodama Jérémie Papassin Rachel Auzely Anaïck Moisan Claire Rome Olivier Detante Biomaterial Applications in Cell-Based Therapy in Experimental Stroke Stem Cells International |
| title | Biomaterial Applications in Cell-Based Therapy in Experimental Stroke |
| title_full | Biomaterial Applications in Cell-Based Therapy in Experimental Stroke |
| title_fullStr | Biomaterial Applications in Cell-Based Therapy in Experimental Stroke |
| title_full_unstemmed | Biomaterial Applications in Cell-Based Therapy in Experimental Stroke |
| title_short | Biomaterial Applications in Cell-Based Therapy in Experimental Stroke |
| title_sort | biomaterial applications in cell based therapy in experimental stroke |
| url | http://dx.doi.org/10.1155/2016/6810562 |
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