Overexpression of oncogenic polo-like kinase 1 disrupts the invasiveness, cell cycle, and apoptosis in synovial sarcoma

Overexpression of oncogenic polo-like kinase 1 disrupts the invasiveness, cell cycle, and apoptosis in synovial sarcoma

Abstract Background Synovial sarcoma (SS) is an aggressive malignant soft tissue sarcoma of undetermined tissue origin that harbors potential metastases and recurrences, leading to a poor prognosis. Polo-like kinase 1 (PLK1) is an essential member of the serine/threonine kinase family, which plays a...

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Bibliographic Details
Main Authors: Jun Zhang, Zhong Li, Ming-Yu Xie, Ning Wang, Hao Liu, Feng Li, Li-Juan Pang, Yan Qi
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Synovial sarcoma
PLK1
BI2536
Invasiveness
Cell cycle
Apoptosis
Online Access:https://doi.org/10.1186/s12967-025-06740-8
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https://doi.org/10.1186/s12967-025-06740-8

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