A mechanism for robust circadian timekeeping via stoichiometric balance

Abstract Circadian (∼24 h) timekeeping is essential for the lives of many organisms. To understand the biochemical mechanisms of this timekeeping, we have developed a detailed mathematical model of the mammalian circadian clock. Our model can accurately predict diverse experimental data including th...

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Bibliographic Details
Main Authors: Jae Kyoung Kim, Daniel B Forger
Format: Article
Language:English
Published: Springer Nature 2012-12-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2012.62
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