Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma

Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma

Background & Aims: The inhibition of epigenetic regulators activates endogenous retrovirus (ERV) expression, which can stimulate a viral mimicry response in cancer cells. ERV elements are aberrantly expressed in hepatocellular carcinoma (HCC); however, the expression of ERVs regulated by his...

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Main Authors: Yosuke Igarashi, Yoshimitsu Akiyama, Shu Shimada, Shuichi Watanabe, Megumi Hatano, Keita Kodera, Kohei Okazaki, Yoshiaki Tanji, Shu Tsukihara, Tomohiko Taniai, Atsushi Nara, Masahiro Yamane, Atsushi Kamachi, Kentaro Umemura, Koya Yasukawa, Hiroaki Ono, Keiichi Akahoshi, Minoru Tanabe, Koichiro Haruki, Kenei Furukawa, Toru Ikegami, Shinji Tanaka
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JHEP Reports
Subjects:
Viral mimicry
Interferon
Tumor immunity
Histone modification
Endogenous retrovirus
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924003112
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