Targeting the proliferation of glioblastoma cells and enhancement of doxorubicin and temozolomide cytotoxicity through inhibition of PFKFB4 and HMOX1 genes with siRNAs

Targeting the proliferation of glioblastoma cells and enhancement of doxorubicin and temozolomide cytotoxicity through inhibition of PFKFB4 and HMOX1 genes with siRNAs

Abstract Glioblastoma multiforme continues to be one of the most aggressive brain cancers, posing a serious health challenge, as it offers a median survival of only 15–23 months and a 5-year survival rate of less than 6%. Current treatments often prove inadequate, underscoring the urgency for new th...

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Main Authors: Hamzeh J. Al-Ameer, Malek Zihlif, Ahmed Maslat, Wajdy J. Al-Awaida, Amani Marwan Ayyash, Amer Imraish, Nidal Al-Qinna, Tareq Al-Omari, Talal Al-Qaisi, Walid Al-Zyoud, Bayan T. Alzubi, Ali M. Atoom, Isam A. Fattash, Shubhankar Ambike, Khang Wen Goh, Yulia Sh. Gushchina
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Glioblastoma
siRNA
PFKFB4
HMOX1
Doxorubicin
Temozolomide
Online Access:https://doi.org/10.1038/s41598-025-97192-z
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https://doi.org/10.1038/s41598-025-97192-z

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