SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota

Abstract Strong evidence indicates that remodeling gut microbiota may be an effective approach to combat Parkinson’s disease (PD). Scorpion Venom Heat-Resistant Synthesized Peptide (SVHRSP), a synthesized peptide discovered from scorpion venom, displays potent neuroprotection in multiple PD models....

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Bibliographic Details
Main Authors: Mengdi Chen, Yu Zhang, Liyan Hou, Zirui Zhao, Peiyan Tang, Qingquan Sun, Jie Zhao, Qingshan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00892-6
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