Targeting GPR84 to alleviate acute immune-mediated liver injury

Targeting GPR84 to alleviate acute immune-mediated liver injury

Abstract Background GPR84 is a Gi-coupled G-protein-coupled receptor (GPCR) predominantly expressed in immune cells, with its expression upregulated during inflammatory conditions. However, its specific role in immune-mediated liver injury remains unclear. Methods We utilized a concanavalin A (Con A...

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Main Authors: Yanan Zheng, Yumeng Wang, Yujie Xu, Shanshan Shen, Haozhe Xu, Chao Hu, Yongzhen Chen, Fengmeng Teng, Jinshun Pan, Shuqian Zheng, Junqi Wang, Zhongping Su, Qiang You
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
GPR84
Immune-mediated liver injury
Inflammation
GLPG1205
Online Access:https://doi.org/10.1186/s10020-025-01248-9
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https://doi.org/10.1186/s10020-025-01248-9

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