Role of KLF5 in enhancing ovarian cancer stemness and PARPi resistance: mechanisms and therapeutic targeting

Role of KLF5 in enhancing ovarian cancer stemness and PARPi resistance: mechanisms and therapeutic targeting

Abstract Background Ovarian cancer (OC) often presents at advanced stages with poor prognosis. Although poly(ADP-ribose) polymerase inhibitors (PARPi) offer clinical benefits, resistance remains a major challenge. This study investigates the role of KLF5 in regulating OC cell stemness and contributi...

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Bibliographic Details
Main Authors: Huimin Xiao, Guiyun Cheng, Haocheng Zhang, Yao Liu, Zhongshao Chen, Yuehan Gao, Feng Gao, Yanling Liu, Shourong Wang, Beihua Kong
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
KLF5
Stemness of cancer cells
PARPi resistance
Vimentin
Online Access:https://doi.org/10.1186/s12967-025-06502-6
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https://doi.org/10.1186/s12967-025-06502-6

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