GD2-CAR NK-92 cell activity against neuroblastoma cells is insusceptible to TIGIT knockout

GD2-CAR NK-92 cell activity against neuroblastoma cells is insusceptible to TIGIT knockout

Abstract Immunotherapy by inhibition of immune checkpoint (IC) molecules has emerged as an important cancer therapy. Among these lC, the poliovirus receptor/poliovirus receptor-like 2 protein (PVR/PVRL2)-TIGIT axis was discovered as potential target for various cancers. For neuroblastoma (NB), the m...

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Bibliographic Details
Main Authors: Wiebke Jünemann, Isabelle Bley, Laura Rekowski, Marianne Klokow, Susanne Herppich, Ingo Müller, Kerstin Cornils
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Neuroblastoma
Immune checkpoint
Immunotherapy
Chimeric antigen receptor
PVR
PVRL2
Online Access:https://doi.org/10.1007/s00262-025-04010-6
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https://doi.org/10.1007/s00262-025-04010-6

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