Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study
Abstract Glioblastoma (GBM), one of the most aggressive brain tumors, has a 5-year survival rate of less than 5%. Current standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, are limited by drug resistance and the blood–brain barrier. Integrating expression quant...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-025-13979-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726122936238080 |
|---|---|
| author | Hongwei Zhang Zixuan Wang Xiaolong Qiao Jiaxing Wu Chuandong Cheng |
| author_facet | Hongwei Zhang Zixuan Wang Xiaolong Qiao Jiaxing Wu Chuandong Cheng |
| author_sort | Hongwei Zhang |
| collection | DOAJ |
| description | Abstract Glioblastoma (GBM), one of the most aggressive brain tumors, has a 5-year survival rate of less than 5%. Current standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, are limited by drug resistance and the blood–brain barrier. Integrating expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) data has shown promise in uncovering disease mechanisms and therapeutic targets. This study combined eQTL and pQTL analyses to identify potential GBM-related genes and circulating plasma proteins for therapeutic exploration. Using transcriptomic data from The Cancer Genome Atlas (TCGA), we identified 2,528 differentially expressed genes, including GPX7 and CXCL10. eQTL-MR analysis identifies GBM-associated differentially expressed genes and constructs a protein–protein interaction (PPI) network.Integrating pQTL data from the deCODE database, pQTL-MR, and colocalization analyses validated the therapeutic potential of GPX7 and CXCL10.These findings provide new perspectives on GBM biology and suggest actionable targets for therapy. Despite limitations due to sample size and population-specific data, this study highlights GPX7 and CXCL10 as promising candidates for further investigation and lays the foundation for targeted GBM treatments. |
| format | Article |
| id | doaj-art-ad68667e7e0047e1969acb977d4a67e9 |
| institution | DOAJ |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-ad68667e7e0047e1969acb977d4a67e92025-08-20T03:10:17ZengBMCBMC Cancer1471-24072025-04-0125111810.1186/s12885-025-13979-3Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization studyHongwei Zhang0Zixuan Wang1Xiaolong Qiao2Jiaxing Wu3Chuandong Cheng4Department of Neurosurgery, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaDepartment of Neurosurgery, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaDepartment of Neurosurgery, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaDepartment of Neurosurgery, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaDepartment of Neurosurgery, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaAbstract Glioblastoma (GBM), one of the most aggressive brain tumors, has a 5-year survival rate of less than 5%. Current standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, are limited by drug resistance and the blood–brain barrier. Integrating expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) data has shown promise in uncovering disease mechanisms and therapeutic targets. This study combined eQTL and pQTL analyses to identify potential GBM-related genes and circulating plasma proteins for therapeutic exploration. Using transcriptomic data from The Cancer Genome Atlas (TCGA), we identified 2,528 differentially expressed genes, including GPX7 and CXCL10. eQTL-MR analysis identifies GBM-associated differentially expressed genes and constructs a protein–protein interaction (PPI) network.Integrating pQTL data from the deCODE database, pQTL-MR, and colocalization analyses validated the therapeutic potential of GPX7 and CXCL10.These findings provide new perspectives on GBM biology and suggest actionable targets for therapy. Despite limitations due to sample size and population-specific data, this study highlights GPX7 and CXCL10 as promising candidates for further investigation and lays the foundation for targeted GBM treatments.https://doi.org/10.1186/s12885-025-13979-3GlioblastomaeQTLpQTLMendelian randomizationGPX7CXCL10 |
| spellingShingle | Hongwei Zhang Zixuan Wang Xiaolong Qiao Jiaxing Wu Chuandong Cheng Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study BMC Cancer Glioblastoma eQTL pQTL Mendelian randomization GPX7 CXCL10 |
| title | Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study |
| title_full | Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study |
| title_fullStr | Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study |
| title_full_unstemmed | Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study |
| title_short | Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study |
| title_sort | investigating potential drug targets for the treatment of glioblastoma a mendelian randomization study |
| topic | Glioblastoma eQTL pQTL Mendelian randomization GPX7 CXCL10 |
| url | https://doi.org/10.1186/s12885-025-13979-3 |
| work_keys_str_mv | AT hongweizhang investigatingpotentialdrugtargetsforthetreatmentofglioblastomaamendelianrandomizationstudy AT zixuanwang investigatingpotentialdrugtargetsforthetreatmentofglioblastomaamendelianrandomizationstudy AT xiaolongqiao investigatingpotentialdrugtargetsforthetreatmentofglioblastomaamendelianrandomizationstudy AT jiaxingwu investigatingpotentialdrugtargetsforthetreatmentofglioblastomaamendelianrandomizationstudy AT chuandongcheng investigatingpotentialdrugtargetsforthetreatmentofglioblastomaamendelianrandomizationstudy |