Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations

Oscillations in insulin secretion, driven by islet Ca2+ waves, are crucial for glycemic control. Prior studies, performed with single-plane imaging, suggest that subpopulations of electrically coupled β-cells have privileged roles in leading and coordinating the propagation of Ca2+ waves. Here, we u...

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Bibliographic Details
Main Authors: Erli Jin, Jennifer K Briggs, Richard KP Benninger, Matthew J Merrins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/103068
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