Characterization of the genome editing with miniature DNA nucleases TnpB and IscB in Escherichia coli strains

Abstract DNA endonucleases TnpB and IscB are emerging candidates for combating drug-resistant bacteria, particularly Escherichia coli, due to their specificity in targeting DNA and smaller size. However, the genome-editing of TnpB/IscB in E. coli remains unclear. This study characterized the genome...

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Bibliographic Details
Main Authors: Hongjie Tang, Jie Gao, Hengyi Wang, Mingjun Sun, Suyi Zhang, Chuan Song, Qi Li
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07521-1
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