Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches

Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches

Perceptual updating has been hypothesised to rely on a network reset modulated by bursts of ascending neuromodulatory neurotransmitters, such as noradrenaline, abruptly altering the brain’s susceptibility to changing sensory activity. To test this hypothesis at a large-scale, we analysed an ambiguou...

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Bibliographic Details
Main Authors: Gabriel Wainstein, Christopher J Whyte, Kaylena A Ehgoetz Martens, Eli J Müller, Vicente Medel, Britt Anderson, Elisabeth Stöttinger, James Danckert, Brandon R Munn, James M Shine
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
fMRI
pupillometry
neural network
switching
perception
neuromodulation
Online Access:https://elifesciences.org/articles/93191
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https://elifesciences.org/articles/93191

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