Development of a CYP11B2 imaging tracer for primary aldosteronism: basic evaluation of iodine- and fluorine-incorporated pyridinyldihydroquinolinone derivatives

Development of a CYP11B2 imaging tracer for primary aldosteronism: basic evaluation of iodine- and fluorine-incorporated pyridinyldihydroquinolinone derivatives

Abstract Background Current methods for diagnosing primary aldosteronism (PA) are limited by their invasiveness and diagnostic accuracy. This study aimed to develop nuclear medicine imaging tracers targeting CYP11B2, which is overexpressed in patients with PA. Results We successfully synthesized iod...

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Main Authors: Yusuke Yagi, Hiroyuki Kimura, Riko Fuseda, Takaaki Murakami, Marina Omokawa, Kaito Ohta, Satoko Kise, Masakatsu Sone, Hiroyuki Yasui, Nobuya Inagaki, Hideo Saji
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
125I
Primary aldosteronism
Positron emission tomography
Single photon emission tomography
Tetrahydropyridoquinolinone
Online Access:https://doi.org/10.1186/s41181-025-00361-8
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https://doi.org/10.1186/s41181-025-00361-8

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