Cell envelope polysaccharide modifications alter the surface properties and interactions of Mycobacterium abscessus with innate immune cells in a morphotype-dependent manner

Cell envelope polysaccharide modifications alter the surface properties and interactions of Mycobacterium abscessus with innate immune cells in a morphotype-dependent manner

ABSTRACT Mycobacterium abscessus is one of the leading causes of pulmonary infections caused by non-tuberculous mycobacteria. The ability of M. abscessus to establish a chronic infection in the lung relies on a series of adaptive mutations impacting, in part, global regulators and cell envelope bios...

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Main Authors: Elena Lian, Juan M. Belardinelli, Kavita De, Arun Prasad Pandurangan, Shiva K. Angala, Zuzana Palčeková, Anna E. Grzegorzewicz, Josephine M. Bryant, Tom L. Blundell, Julian Parkhill, R. Andres Floto, William H. Wheat, Mary Jackson
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
Mycobacterium abscessus
non-tuberculous mycobacteria
lipoarabinomannan
arabinogalactan
biofilm
morphotype
Online Access:https://journals.asm.org/doi/10.1128/mbio.00322-25
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https://journals.asm.org/doi/10.1128/mbio.00322-25

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