Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

Abstract Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate neuroblastoma cells from the bone marrow during post-chemo maintenance therapy—...

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Main Authors: Min Pan, Yinwen Zhang, William C. Wright, Xueying Liu, Barbara Passaia, Duane Currier, Jonathan Low, Richard H. Chapple, Jacob A. Steele, Jon P. Connelly, Bensheng Ju, Emily Plyler, Meifen Lu, Allister J. Loughran, Lei Yang, Brian J. Abraham, Shondra M. Pruett-Miller, Burgess Freeman, George E. Campbell, Michael A. Dyer, Taosheng Chen, Elizabeth Stewart, Selene Koo, Heather Sheppard, John Easton, Paul Geeleher
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57185-y
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https://doi.org/10.1038/s41467-025-57185-y

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