Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease

Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease

Abstract Preliminary evidence suggests perturbations of the kynurenine pathway (KP) of tryptophan metabolism in infants with single ventricle heart disease (SVHD). In 72 infants with SVHD undergoing stage 2 palliation (S2P) and 41 controls, we quantified serum KP metabolite concentrations via tandem...

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Main Authors: Jennifer Romanowicz, Sierra Niemiec, Ludmila Khailova, Tanner Lehmann, Christopher A. Mancuso, Max B. Mitchell, Gareth J. Morgan, Mark Twite, Michael V. DiMaria, Jelena Klawitter, Jesse A. Davidson, Benjamin S. Frank
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Physiological Reports
Subjects:
cardiac surgery
congenital heart disease
Glenn
kynurenic acid
serotonin
Online Access:https://doi.org/10.14814/phy2.70133
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https://doi.org/10.14814/phy2.70133

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