Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.

<h4>Background</h4>Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood.<h4>M...

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Main Authors: Peter Würtz, Qin Wang, Antti J Kangas, Rebecca C Richmond, Joni Skarp, Mika Tiainen, Tuulia Tynkkynen, Pasi Soininen, Aki S Havulinna, Marika Kaakinen, Jorma S Viikari, Markku J Savolainen, Mika Kähönen, Terho Lehtimäki, Satu Männistö, Stefan Blankenberg, Tanja Zeller, Jaana Laitinen, Anneli Pouta, Pekka Mäntyselkä, Mauno Vanhala, Paul Elliott, Kirsi H Pietiläinen, Samuli Ripatti, Veikko Salomaa, Olli T Raitakari, Marjo-Riitta Järvelin, George Davey Smith, Mika Ala-Korpela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1001765
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https://doi.org/10.1371/journal.pmed.1001765

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