Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies
Abstract Staphylococcus aureus is a common cause of biofilm infections, particularly on implanted medical devices. Biofilms are heterogeneous bacterial communities contained in a self-produced matrix that are poorly cleared by the immune system. This review discusses mechanisms employed by the biofi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00782-y |
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| author | Nichole D. Brandquist Tammy Kielian |
| author_facet | Nichole D. Brandquist Tammy Kielian |
| author_sort | Nichole D. Brandquist |
| collection | DOAJ |
| description | Abstract Staphylococcus aureus is a common cause of biofilm infections, particularly on implanted medical devices. Biofilms are heterogeneous bacterial communities contained in a self-produced matrix that are poorly cleared by the immune system. This review discusses mechanisms employed by the biofilm, such as alterations in bacterial metabolism and toxin production, to induce immune dysfunction by highlighting recent bacterial single-cell sequencing studies. Additionally, the role of immune recognition and metabolism in biofilm containment is examined with an emphasis on the role of granulocytic myeloid-derived suppressor cells and how responses are tailored to distinct tissue niches. We also address emerging evidence revealing the importance of the infection microenvironment, host genetic variability, and bacterial heterogeneity in shaping immune responses during S. aureus biofilm infections. |
| format | Article |
| id | doaj-art-ad10974ad09645e8a23a878acaa9112c |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-ad10974ad09645e8a23a878acaa9112c2025-08-20T04:01:53ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-07-0111111510.1038/s41522-025-00782-yImmune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategiesNichole D. Brandquist0Tammy Kielian1Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical CenterDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical CenterAbstract Staphylococcus aureus is a common cause of biofilm infections, particularly on implanted medical devices. Biofilms are heterogeneous bacterial communities contained in a self-produced matrix that are poorly cleared by the immune system. This review discusses mechanisms employed by the biofilm, such as alterations in bacterial metabolism and toxin production, to induce immune dysfunction by highlighting recent bacterial single-cell sequencing studies. Additionally, the role of immune recognition and metabolism in biofilm containment is examined with an emphasis on the role of granulocytic myeloid-derived suppressor cells and how responses are tailored to distinct tissue niches. We also address emerging evidence revealing the importance of the infection microenvironment, host genetic variability, and bacterial heterogeneity in shaping immune responses during S. aureus biofilm infections.https://doi.org/10.1038/s41522-025-00782-y |
| spellingShingle | Nichole D. Brandquist Tammy Kielian Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies npj Biofilms and Microbiomes |
| title | Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies |
| title_full | Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies |
| title_fullStr | Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies |
| title_full_unstemmed | Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies |
| title_short | Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies |
| title_sort | immune dysfunction during s aureus biofilm associated implant infections opportunities for novel therapeutic strategies |
| url | https://doi.org/10.1038/s41522-025-00782-y |
| work_keys_str_mv | AT nicholedbrandquist immunedysfunctionduringsaureusbiofilmassociatedimplantinfectionsopportunitiesfornoveltherapeuticstrategies AT tammykielian immunedysfunctionduringsaureusbiofilmassociatedimplantinfectionsopportunitiesfornoveltherapeuticstrategies |