Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy
Cervical cancer is the second leading cause of cancer-related deaths among women worldwide. Despite advancements in screening programs and vaccination efforts, a significant proportion of patients present with advanced-stage disease, characterized by severe manifestations and a poor prognosis. Clini...
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| Format: | Article |
| Language: | English |
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Universitas Sultan Agung Semarang
2024-12-01
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| Series: | Sains Medika |
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| Online Access: | https://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/28943 |
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| author | I Nyoman Bayu Mahendra I Gde Sastra Winata William Alexander Setiawan Ida Bagus Agung Widnyana Putra Putu Bagus Darmayasa |
| author_facet | I Nyoman Bayu Mahendra I Gde Sastra Winata William Alexander Setiawan Ida Bagus Agung Widnyana Putra Putu Bagus Darmayasa |
| author_sort | I Nyoman Bayu Mahendra |
| collection | DOAJ |
| description | Cervical cancer is the second leading cause of cancer-related deaths among women worldwide. Despite advancements in screening programs and vaccination efforts, a significant proportion of patients present with advanced-stage disease, characterized by severe manifestations and a poor prognosis. Clinical evidence highlights substantial variability in the sensitivity of chemotherapy regimens among cervical cancer patients, often resulting in suboptimal therapeutic outcomes and increased risk of complications. This underscores the need for reliable molecular markers to predict prognosis and optimize therapy. Angiogenesis plays a pivotal role in the development and progression of solid tumors, including cervical cancer. Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. Studies have demonstrated significant correlations between VEGF levels and important prognostic parameters, including tumor size, metastasis, and chemotherapy response. Consequently, tumor angiogenesis markers like VEGF and VEGFR hold potential as valuable predictive tools to guide the management of advanced cervical cancer, particularly in patients undergoing chemotherapy. |
| format | Article |
| id | doaj-art-ad1090ee673342bdab9f2ef8033854a6 |
| institution | Kabale University |
| issn | 2085-1545 2339-093X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universitas Sultan Agung Semarang |
| record_format | Article |
| series | Sains Medika |
| spelling | doaj-art-ad1090ee673342bdab9f2ef8033854a62025-02-03T08:04:34ZengUniversitas Sultan Agung SemarangSains Medika2085-15452339-093X2024-12-01152889510.30659/sainsmed.v15i2.2894310453Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapyI Nyoman Bayu Mahendra0I Gde Sastra Winata1William Alexander Setiawan2Ida Bagus Agung Widnyana Putra3Putu Bagus Darmayasa4Department of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, BaliDepartment of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, BaliDepartment of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, BaliDepartment of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, BaliDepartment of Obstetrics and Gynecology Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, Denpasar, BaliCervical cancer is the second leading cause of cancer-related deaths among women worldwide. Despite advancements in screening programs and vaccination efforts, a significant proportion of patients present with advanced-stage disease, characterized by severe manifestations and a poor prognosis. Clinical evidence highlights substantial variability in the sensitivity of chemotherapy regimens among cervical cancer patients, often resulting in suboptimal therapeutic outcomes and increased risk of complications. This underscores the need for reliable molecular markers to predict prognosis and optimize therapy. Angiogenesis plays a pivotal role in the development and progression of solid tumors, including cervical cancer. Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. Studies have demonstrated significant correlations between VEGF levels and important prognostic parameters, including tumor size, metastasis, and chemotherapy response. Consequently, tumor angiogenesis markers like VEGF and VEGFR hold potential as valuable predictive tools to guide the management of advanced cervical cancer, particularly in patients undergoing chemotherapy.https://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/28943advanced cervical cancer, chemotherapy, prognosis, vegf, vegfr |
| spellingShingle | I Nyoman Bayu Mahendra I Gde Sastra Winata William Alexander Setiawan Ida Bagus Agung Widnyana Putra Putu Bagus Darmayasa Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy Sains Medika advanced cervical cancer, chemotherapy, prognosis, vegf, vegfr |
| title | Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy |
| title_full | Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy |
| title_fullStr | Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy |
| title_full_unstemmed | Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy |
| title_short | Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy |
| title_sort | prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy |
| topic | advanced cervical cancer, chemotherapy, prognosis, vegf, vegfr |
| url | https://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/28943 |
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