Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice

Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice

FoxP3+ regulatory T (Treg) cells restrict excessive immune responses and immunopathology as well as reactivity to self or environmental antigens and thus are crucial for peripheral immune tolerance. The transcription factor Interferon Regulatory Factor 4 (IRF4) controls differentiation and function...

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Bibliographic Details
Main Authors:	Leonie Caroline Voß, Constantin Schmidt, Aenne Harberts, Michael Spohn, Peter Bradtke, Alina Borchers, Stefanie Fertig, Joanna Schmid, Friedrich Koch-Nolte, Christian F. Krebs, Friederike Raczkowski, Hans-Willi Mittrücker
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	Interferon Regulatory Factor 4 T cells regulatory T cells FoxP3 assay for transposase-accessible chromatin (ATAC) sequencing
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604888/full
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