Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice

Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice

FoxP3+ regulatory T (Treg) cells restrict excessive immune responses and immunopathology as well as reactivity to self or environmental antigens and thus are crucial for peripheral immune tolerance. The transcription factor Interferon Regulatory Factor 4 (IRF4) controls differentiation and function...

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Main Authors: Leonie Caroline Voß, Constantin Schmidt, Aenne Harberts, Michael Spohn, Peter Bradtke, Alina Borchers, Stefanie Fertig, Joanna Schmid, Friedrich Koch-Nolte, Christian F. Krebs, Friederike Raczkowski, Hans-Willi Mittrücker
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Interferon Regulatory Factor 4
T cells
regulatory T cells
FoxP3
assay for transposase-accessible chromatin (ATAC) sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604888/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604888/full

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