Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility

Abstract High-risk human papillomaviruses (HPVs) cause various cancers. While type-specific prophylactic vaccines are available, additional anti-viral strategies are highly desirable. Initial HPV cell entry involves receptor-switching induced by structural capsid modifications. These modifications a...

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Main Authors: Yuzhen Feng, Dominik van Bodegraven, Alan Kádek, Ignacio L. B. Munguira, Laura Soria-Martinez, Sarah Nentwich, Sreedeepa Saha, Florian Chardon, Daniel Kavan, Charlotte Uetrecht, Mario Schelhaas, Wouter H. Roos
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54373-0
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https://doi.org/10.1038/s41467-024-54373-0

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