Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Abstract The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped 5′ ends of mRNAs, additionally reveals a large number of apparently 5′ capped RNAs d...

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Main Authors: Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M. Chakrabarti, Andrew M. Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R. Sibley, Aida Martinez-Sanchez, Boris Lenhard
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Biology
Subjects:
3′UTR
CAGE
Capping
AGO2
UPF1
3′UTR-derived RNA
Online Access:https://doi.org/10.1186/s12915-024-02032-7
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https://doi.org/10.1186/s12915-024-02032-7

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