Maintenance of pluripotency and osteogenic differentiation of human mesenchymal stem cells on acrylate-based substrates exhibiting gelatin or heparin grafting

Maintenance of pluripotency and osteogenic differentiation of human mesenchymal stem cells on acrylate-based substrates exhibiting gelatin or heparin grafting

Abstract This study investigated the in vitro biological behaviour of human mesenchymal stem cells grown on acrylate-based substrates functionalized with biomolecules that play a significant role in the extracellular matrix, specifically gelatin (derived from collagen) and heparin. Synthetic support...

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Main Authors: María Noel Tamaño-Machiavello, Juan Carlos Marín Payá, Silvia Flores, Lourdes Cordón, Amparo Sempere, Roser Sabater i Serra, José Luis Gómez Ribelles
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Acrylate cell substrates
Gelatin/heparin grafting
Human bone marrow mesenchymal stem cells
Osteogenic differentiation
Pluripotency markers
Online Access:https://doi.org/10.1038/s41598-025-05640-7
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https://doi.org/10.1038/s41598-025-05640-7

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