Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice

Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice

Background and aimsCell death plays a central role in atheroma plaque progression and aggravation. This study investigates the role of caspase-8 in regulating macrophage cell death modalities, specifically apoptosis and necroptosis, within atheroma plaques.MethodsBone marrow from caspase-8-deficient...

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Bibliographic Details
Main Authors: Thomas Pilot, Stéphanie Solier, Antoine Jalil, Charlène Magnani, Tom Vanden Berghe, Peter Vandenabeele, David Masson, Eric Solary, Charles Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
apoptosis
necroptosis
necrotic core
macrophages
caspase-8
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513637/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513637/full

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