High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked statistical power and genetic resolution to fully define MHC influences. We characterized 1,610 Caucasi...

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Main Authors: Lisa F Barcellos, Suzanne L May, Patricia P Ramsay, Hong L Quach, Julie A Lane, Joanne Nititham, Janelle A Noble, Kimberly E Taylor, Diana L Quach, Sharon A Chung, Jennifer A Kelly, Kathy L Moser, Timothy W Behrens, Michael F Seldin, Glenys Thomson, John B Harley, Patrick M Gaffney, Lindsey A Criswell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000696&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000696&type=printable

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