Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells

Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells

Abstract Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as atherosclerosis, coronary artery disease, and hypertension. Conventiona...

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Main Authors: Hana A. Mohamed, Nura A. Mohamed, Shantelle S. Macasa, Hamda K. Basha, Adna M. Adan, Sergio Crovella, Hong Ding, Christopher R. Triggle, Isra Marei, Haissam Abou-Saleh
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
NanoMIL-89
Metformin
Diabetes mellitus
Nanomedicine
Cardiovascular complications
Drug delivery
Online Access:https://doi.org/10.1038/s41598-024-81427-6
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https://doi.org/10.1038/s41598-024-81427-6

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