Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study.
<h4>Purpose</h4>To compare the efficacy of a 0.15% HA with that of 0.1% HA eye drops for DES after cataract surgery.<h4>Methods</h4>This study was double blinded, randomized and prospective study, and conducted in 69 participants (70 eyes) from Pusan National University Yangs...
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Public Library of Science (PLoS)
2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0306253 |
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| author | Seung Ahn Yang Mu Ryang Jeong Cheon Ho Park Ki Bum Cheon Jun Ho Chang Ji Eun Lee |
| author_facet | Seung Ahn Yang Mu Ryang Jeong Cheon Ho Park Ki Bum Cheon Jun Ho Chang Ji Eun Lee |
| author_sort | Seung Ahn Yang |
| collection | DOAJ |
| description | <h4>Purpose</h4>To compare the efficacy of a 0.15% HA with that of 0.1% HA eye drops for DES after cataract surgery.<h4>Methods</h4>This study was double blinded, randomized and prospective study, and conducted in 69 participants (70 eyes) from Pusan National University Yangsan Hospital and executed from February 1, 2022 to November 30, 2022. Participants were adult cataract patients with normal lid position, not suffering from any other ocular disease and not meet the exclusion cirteria of clinical trial. Participants were randomly divided into two groups: 35 participants (17 males and 18 females) in the 0.1% HA group and 34 participants (19 males and 15 females) in the 0.15% HA group, receiving treatment six times daily for 6 weeks following cataract surgery. Subjective and objective assessments were performed at preoperative and postoperative visits, including ocular surface disease index score, tear break up time, corneal staining score, Schirmer's I test score, lipid layer thickness), meiboscore, and biochemical analysis of the eye drops.<h4>Results</h4>Throughout the study, the postoperative ocular surface disease index score was significantly lower in the group receiving 0.15% hyaluronic acid than in the group receiving 0.1% hyaluronic acid. Additionally, the postoperative ocular surface disease index score showed a significant positive correlation with the postoperative use of 0.15% hyaluronic acid and the preoperative Schirmer's I test score. In multivariate analysis, treatment with 0.15% hyaluronic acid and the preoperative ocular surface disease index score were significant independent parameters affecting the postoperative ocular surface disease index score.<h4>Conclusion</h4>The use of 0.15% hyaluronic acid is recommended for its potential advantages in alleviating symptoms following cataract surgery, making it a viable alternative to traditional 0.1% hyaluronic acid treatment.<h4>Trial registration</h4>ISRCTN95830348. |
| format | Article |
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| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-acc7a396ff3f42b4a62d237c614c49e22025-01-03T01:54:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01197e030625310.1371/journal.pone.0306253Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study.Seung Ahn YangMu Ryang JeongCheon Ho ParkKi Bum CheonJun Ho ChangJi Eun Lee<h4>Purpose</h4>To compare the efficacy of a 0.15% HA with that of 0.1% HA eye drops for DES after cataract surgery.<h4>Methods</h4>This study was double blinded, randomized and prospective study, and conducted in 69 participants (70 eyes) from Pusan National University Yangsan Hospital and executed from February 1, 2022 to November 30, 2022. Participants were adult cataract patients with normal lid position, not suffering from any other ocular disease and not meet the exclusion cirteria of clinical trial. Participants were randomly divided into two groups: 35 participants (17 males and 18 females) in the 0.1% HA group and 34 participants (19 males and 15 females) in the 0.15% HA group, receiving treatment six times daily for 6 weeks following cataract surgery. Subjective and objective assessments were performed at preoperative and postoperative visits, including ocular surface disease index score, tear break up time, corneal staining score, Schirmer's I test score, lipid layer thickness), meiboscore, and biochemical analysis of the eye drops.<h4>Results</h4>Throughout the study, the postoperative ocular surface disease index score was significantly lower in the group receiving 0.15% hyaluronic acid than in the group receiving 0.1% hyaluronic acid. Additionally, the postoperative ocular surface disease index score showed a significant positive correlation with the postoperative use of 0.15% hyaluronic acid and the preoperative Schirmer's I test score. In multivariate analysis, treatment with 0.15% hyaluronic acid and the preoperative ocular surface disease index score were significant independent parameters affecting the postoperative ocular surface disease index score.<h4>Conclusion</h4>The use of 0.15% hyaluronic acid is recommended for its potential advantages in alleviating symptoms following cataract surgery, making it a viable alternative to traditional 0.1% hyaluronic acid treatment.<h4>Trial registration</h4>ISRCTN95830348.https://doi.org/10.1371/journal.pone.0306253 |
| spellingShingle | Seung Ahn Yang Mu Ryang Jeong Cheon Ho Park Ki Bum Cheon Jun Ho Chang Ji Eun Lee Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study. PLoS ONE |
| title | Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study. |
| title_full | Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study. |
| title_fullStr | Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study. |
| title_full_unstemmed | Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study. |
| title_short | Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study. |
| title_sort | comparative efficacy of 0 1 and 0 15 sodium hyaluronate on lipid layer and meibomian glands following cataract surgery a randomized prospective study |
| url | https://doi.org/10.1371/journal.pone.0306253 |
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