Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis: a comparative study

Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis: a comparative study

IntroductionDrug resistance (DR) of pathogens remains a global healthcare concern. In contrast to other bacteria, acquiring mutations in the core genome is the main mechanism of drug resistance for Mycobacterium tuberculosis (MTB). For some antibiotics, the resistance of a particular isolate can be...

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Main Authors: Kirill Reshetnikov, Daria Bykova, Konstantin Kuleshov, Konstantin Chukreev, Egor Guguchkin, Alexey Neverov, Gennady Fedonin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
antimicrobial drug resistance
feature selection
machine learning
PFAM domains
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1586476/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1586476/full

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