Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and result in massive bone loss. During RANKL‐induced osteoclastogenesis, pyroptosis of macrophages/preosteoclasts acts as a pivotal mechanism for IL‐1β release, thereby promoting osteoclast maturatio...

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Main Authors: Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
inflammatory related bone loss
NEK7
osteoclastogenesis
Pinosylvin
pyroptosis
Online Access:https://doi.org/10.1002/advs.202501532
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https://doi.org/10.1002/advs.202501532

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