Decoding GNAO1 mutations using Caenorhabditis elegans model system: past approaches and future prospectives

Decoding GNAO1 mutations using Caenorhabditis elegans model system: past approaches and future prospectives

GNAO1 encephalopathies are a group of neglected genetic disorders primarily occurring due to de novo mutations in the Gαo protein-encoding gene. This gene is reported to be highly conserved among Caenorhabditis elegans (C. elegans) and humans, with a sequence similarity of nearly 80%. The C. elegans...

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Bibliographic Details
Main Authors: Shubham Yadav, Satya Santoshi Veliventi, Somya Bhandari, Sakshi Gangurde, Shreeya Naik, Shraddha N. Bhagwat, Santosh Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Caenorhabditis elegans (C. elegans)
GNAO1 encephalopathy
Gαo
G-proteins
mutations
disorders
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1633744/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1633744/full

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