Longitudinal kinetics of the viral infection biomarker 3′-deoxy-3′,4′-didehydro-cytidine in SARS-CoV-2, influenza A virus and RSV human challenge models

Longitudinal kinetics of the viral infection biomarker 3′-deoxy-3′,4′-didehydro-cytidine in SARS-CoV-2, influenza A virus and RSV human challenge models

Abstract 3’-deoxy-3’,4’-didehydro-cytidine (ddhC) is a recently discovered host biomarker for viral infections, though its temporal kinetics remain unclear. This study tests the hypothesis that ddhC is an acute phase reactant, rising shortly after viral infection and subsequently falling to baseline...

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Main Authors: Ravi Mehta, Elena Chekmeneva, Stephanie Ascough, Helen Wagstaffe, Loukas Papargyris, Malick Gibani, Ada H. Y. Yuen, Maria Valdivia-Garcia, Caroline Sands, María Gómez-Romero, Ewurabena A. Mills, Vincenzo Sgro, Lydia Slater, Pete Dayananda, Claire Broderick, Jiayun Xu, Myrsini Kaforou, Lynn Maslen, Mahdad Noursadeghi, Andrew J. Pollard, Wendy Barclay, Zoltan Takats, Christopher Chiu, Shiranee Sriskandan
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00132-x
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https://doi.org/10.1038/s44298-025-00132-x

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