CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance

CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance

Abstract Most genetic alterations that drive melanoma development and resistance to targeted therapy have been uncovered. In contrast, and despite their increasingly recognized contribution, little is known about the non‐genetic mechanisms that drive these processes. Here, we performed in vivo gain‐...

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Main Authors: Arthur Gautron, Laura Bachelot, Marc Aubry, Delphine Leclerc, Anaïs M Quéméner, Sébastien Corre, Florian Rambow, Anaïs Paris, Nina Tardif, Héloïse M Leclair, Oskar Marin‐Bejar, Cédric Coulouarn, Jean‐Christophe Marine, Marie‐Dominique Galibert, David Gilot
Format: Article
Language:English
Published: Springer Nature 2021-03-01
Series:EMBO Molecular Medicine
Subjects:
Aryl hydrocarbon Receptor
CRISPR‐SAM
melanoma
SMAD3
targeted therapy resistance
Online Access:https://doi.org/10.15252/emmm.202013466
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https://doi.org/10.15252/emmm.202013466

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