Phthalates promote lenvatinib resistance in hepatocellular carcinoma through the HPX-MAPK pathway

Lenvatinib resistance is a major obstacle in the treatment of hepatocellular carcinoma (HCC). Phthalates, widespread environmental plasticizers, may contribute to therapeutic resistance, yet their impact on HCC remains unclear. In this study, we integrated network toxicology, molecular docking, and...

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Bibliographic Details
Main Authors: Jinlu Han, Chen Wang, Yun Song, Hong Hu, Mengyan Chen, De Zhao, Qiong Wu, Ling Xu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
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Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325012771
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