Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation

Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation

Abstract Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging and deep sequencing. However, proteins are the main drivers of cellular function and in‐depth characterization of individual cells by mass spectrometry (MS)‐based proteomics would thus be highly val...

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Main Authors: Andreas‐David Brunner, Marvin Thielert, Catherine Vasilopoulou, Constantin Ammar, Fabian Coscia, Andreas Mund, Ole B Hoerning, Nicolai Bache, Amalia Apalategui, Markus Lubeck, Sabrina Richter, David S Fischer, Oliver Raether, Melvin A Park, Florian Meier, Fabian J Theis, Matthias Mann
Format: Article
Language:English
Published: Springer Nature 2022-02-01
Series:Molecular Systems Biology
Subjects:
drug perturbation
low‐flow LC–MS
proteomics at single‐cell resolution
single‐cell heterogeneity
systems biology
Online Access:https://doi.org/10.15252/msb.202110798
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https://doi.org/10.15252/msb.202110798

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