Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas

Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas

Immune checkpoint inhibitor-diabetes (CPI-D) is an acute and non-resolving immune-related adverse event (irAE) initiated primarily by disrupting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis with monoclonal antibodies. A major limitation in understanding CPI-D is the lack of a...

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Main Authors: Todd M Brusko, Ana Luisa Perdigoto, Kevan C Herold, Zoe Quandt, Arabella Young, Garry Nolan, Jee Hye Kang, Mark S Anderson, Paul L Bollyky, Graham Larson Barlow, Jennifer A Smith, Irina Kusmartseva, Shen Dong, Melanie R Shapiro, Jamie L Felton, Vinh Q Nguyen, Greg Szot, Assad A Hassoun, Maki Nakayama, Stewart Cooper
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/8/e011818.full
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https://jitc.bmj.com/content/13/8/e011818.full

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