Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II
Arterial hypertension has a high prevalence in the population and is considered both a cardiovascular disease and an important risk factor for the development of other cardiovascular diseases. Tea consumption shows antihypertensive effects due to its composition in terms of bioactive substances such...
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2025-01-01
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| author | Mario de la Fuente-Muñoz Marta Román-Carmena Sara Amor María C. Iglesias-de la Cruz Patricia Martorell Sonia Guilera-Bermell Reme García Bou Antonio M. Inarejos-García Ángel L. García-Villalón Miriam Granado |
| author_facet | Mario de la Fuente-Muñoz Marta Román-Carmena Sara Amor María C. Iglesias-de la Cruz Patricia Martorell Sonia Guilera-Bermell Reme García Bou Antonio M. Inarejos-García Ángel L. García-Villalón Miriam Granado |
| author_sort | Mario de la Fuente-Muñoz |
| collection | DOAJ |
| description | Arterial hypertension has a high prevalence in the population and is considered both a cardiovascular disease and an important risk factor for the development of other cardiovascular diseases. Tea consumption shows antihypertensive effects due to its composition in terms of bioactive substances such as flavan-3-ols and xanthines. The aim of this study was to assess the possible beneficial effects of two tea extracts, one of white tea (ADM<sup>®</sup> White Tea; WTE) and another one composed of a mixture of black tea and green tea (ADM<sup>®</sup> Tea Complex; CTE), on the cardiovascular alterations induced by angiotensin II (AngII) infusion in mice. For this purpose, four groups of C57BL/6J male mice were used: (1) mice fed on a standard diet for 8 weeks and infused with saline for the last 4 weeks (controls); (2) mice fed on a standard diet for 8 weeks and infused with AngII for the last 4 weeks (AngII); (3) mice fed on a standard diet supplemented with 1.6% WTE and infused with AngII for the last 4 weeks (AngII + WTE); (4) mice fed on a standard diet supplemented with 1.6% TC and infused with AngII for the last 4 weeks (AngII + CTE). Both tea extracts exerted anti-inflammatory and antioxidant effects in arterial tissue and reduced AngII-induced endothelial dysfunction in aorta segments. Moreover, supplementation with WTE or CTE reduced the Ang-II-induced overexpression of AT1R and increased AngII-induced downregulation of AT2R in arterial tissue. However, only supplementation with CTE significantly increased the circulating levels of angiotensin 1-7 and reduced systolic blood pressure. In the heart, supplementation with both tea extracts attenuated AngII-induced cardiac hypertrophy and reduced ischemia-reperfusion-induced oxidative stress and apoptosis in myocardial tissue. In conclusion, supplementation with WTE or CTE attenuates AngII-induced cardiovascular damage through their anti-inflammatory, antioxidant, and antiapoptotic effects. In addition, supplementation with CTE also exerts antihypertensive effects, and so it may constitute an avenue through which to support cardiovascular health. |
| format | Article |
| id | doaj-art-ac701dba28f34eb380caa705f337eece |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Antioxidants |
| spelling | doaj-art-ac701dba28f34eb380caa705f337eece2025-01-24T13:19:18ZengMDPI AGAntioxidants2076-39212025-01-011414710.3390/antiox14010047Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin IIMario de la Fuente-Muñoz0Marta Román-Carmena1Sara Amor2María C. Iglesias-de la Cruz3Patricia Martorell4Sonia Guilera-Bermell5Reme García Bou6Antonio M. Inarejos-García7Ángel L. García-Villalón8Miriam Granado9Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainNutrition Archer Daniels Midland (ADM) Health & Wellness, Biopolis S. L. Parc Cientific, Universitat de València, 46980 Paterna, SpainR&D Department of Functional Extracts, ADM, 46740 Valencia, SpainR&D Department of Functional Extracts, ADM, 46740 Valencia, SpainR&D Department of Functional Extracts, ADM, 46740 Valencia, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainDepartamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainArterial hypertension has a high prevalence in the population and is considered both a cardiovascular disease and an important risk factor for the development of other cardiovascular diseases. Tea consumption shows antihypertensive effects due to its composition in terms of bioactive substances such as flavan-3-ols and xanthines. The aim of this study was to assess the possible beneficial effects of two tea extracts, one of white tea (ADM<sup>®</sup> White Tea; WTE) and another one composed of a mixture of black tea and green tea (ADM<sup>®</sup> Tea Complex; CTE), on the cardiovascular alterations induced by angiotensin II (AngII) infusion in mice. For this purpose, four groups of C57BL/6J male mice were used: (1) mice fed on a standard diet for 8 weeks and infused with saline for the last 4 weeks (controls); (2) mice fed on a standard diet for 8 weeks and infused with AngII for the last 4 weeks (AngII); (3) mice fed on a standard diet supplemented with 1.6% WTE and infused with AngII for the last 4 weeks (AngII + WTE); (4) mice fed on a standard diet supplemented with 1.6% TC and infused with AngII for the last 4 weeks (AngII + CTE). Both tea extracts exerted anti-inflammatory and antioxidant effects in arterial tissue and reduced AngII-induced endothelial dysfunction in aorta segments. Moreover, supplementation with WTE or CTE reduced the Ang-II-induced overexpression of AT1R and increased AngII-induced downregulation of AT2R in arterial tissue. However, only supplementation with CTE significantly increased the circulating levels of angiotensin 1-7 and reduced systolic blood pressure. In the heart, supplementation with both tea extracts attenuated AngII-induced cardiac hypertrophy and reduced ischemia-reperfusion-induced oxidative stress and apoptosis in myocardial tissue. In conclusion, supplementation with WTE or CTE attenuates AngII-induced cardiovascular damage through their anti-inflammatory, antioxidant, and antiapoptotic effects. In addition, supplementation with CTE also exerts antihypertensive effects, and so it may constitute an avenue through which to support cardiovascular health.https://www.mdpi.com/2076-3921/14/1/47cardiovascularhypertensionangiotensin IIgreen teablack teawhite tea |
| spellingShingle | Mario de la Fuente-Muñoz Marta Román-Carmena Sara Amor María C. Iglesias-de la Cruz Patricia Martorell Sonia Guilera-Bermell Reme García Bou Antonio M. Inarejos-García Ángel L. García-Villalón Miriam Granado Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II Antioxidants cardiovascular hypertension angiotensin II green tea black tea white tea |
| title | Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II |
| title_full | Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II |
| title_fullStr | Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II |
| title_full_unstemmed | Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II |
| title_short | Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II |
| title_sort | supplementation with standardized green black or white tea extracts attenuates hypertension and ischemia reperfusion induced myocardial damage in mice infused with angiotensin ii |
| topic | cardiovascular hypertension angiotensin II green tea black tea white tea |
| url | https://www.mdpi.com/2076-3921/14/1/47 |
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