Correlation of precisely fabricated geometric characteristics of DNA-origami nanostructures with their cellular entry in human lens epithelial cells

Correlation of precisely fabricated geometric characteristics of DNA-origami nanostructures with their cellular entry in human lens epithelial cells

Abstract Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g., mitochondrion and nucleus), is a key step in engineering cell...

Full description

Saved in:
Bibliographic Details
Main Authors: Yexuan Guo, Tianze Xiong, Hong Yan, Rui Xue Zhang
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Nano
Subjects:
DNA nanotechnology
Ocular delivery
Computer-aided design
Bottom-up
DNA bending rigidity
Mitochondria
Online Access:https://doi.org/10.1186/s11671-025-04188-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s11671-025-04188-9

Similar Items