An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

Adverse outcome pathways (AOPs) have been developed as a risk assessment tool for regulatory applications. These AOPs describe a logical mechanistic sequence of events, starting with a Molecular Initiating Event (MIE), and ultimately leading to a disease outcome via a series of Key Events (KE). The...

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Bibliographic Details
Main Authors: Patrudu Makena, Linsey E. Haswell, Michael McEwan, Brian M. Keyser, David E. Smart, Robert Leverette, Kristen Jordan, Damien Breheny, Sarah Baxter-Wright
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Toxicology
Subjects:
cigarette smoking
atherosclerosis
CVD
oxidative stress
inflammation
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1554747/full
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https://www.frontiersin.org/articles/10.3389/ftox.2025.1554747/full

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