FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury

FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury

Introduction Ferroptosis is a new type of cell death characterized by lipid peroxidation and iron dependency, representing an emerging disease regulation mechanism. The limited understanding of ferroptosis in peripheral nerve injury (PNI) complicates the management of such injuries. Mitochondrial dy...

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Bibliographic Details
Main Authors: Yao Yan, Xinyu Ran, Zihan Zhou, Yuting Gu, Rendu Wang, Chuanqi Qiu, Yinuo Sun, Jifeng Wang, Jian Xiao, Yingfeng Lu, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
peripheral nerve injury
ferroptosis
mitochondria
fibroblast growth factor 21 (FGF21)
schwann cell
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1358646/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1358646/full

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