Uncovering candidate Nanog-Helper genes in early mouse embryo differentiation using differential entropy and network inference
Abstract In the preimplantation mammalian embryo, stochastic cell-to-cell expression heterogeneity is followed by signal reinforcement to initiate the specification of Inner Cell Mass (ICM) cells into Epiblast (Epi). The expression of NANOG, the key transcription factor for the Epi fate, is necessar...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-03956-y |
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